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TGF beta antibody [2C5]

Cat. No. GTX18679

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 2C5

Isotype

 IgG1

Application

 WB, ELISA

Reactivity

 Human
Package
250 μg ($399)
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APPLICATION

Application Note

ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This antibody reacts with the dimeric (25 kDa) and monomeric (12.5 kDa) forms of TGF beta. When used at an antibody concentration of 5-20 ng/mL, GTX18679 will allow visualization of 100 ng/lane of TGF beta Detects a band of approximately 25 and 12.5 kDa. Optimal dilutions/concentrations should be determined by the end user.

Product Note

Western blotting demonstrated that this antibody reacts with the dimeric (25 kDa) and monomeric (12.5 kDa.) forms of TGF beta under both non-reducing and reducing conditions respectively. This antibody recognizes both human platelet-derived and recombinant TGF beta in ELISA.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

TGF beta from human platelets.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Cellular Localization

Secreted

Background

TGF beta is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGF beta acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGF-beta activation and signaling may result in apoptosis. Many cells synthesize TGF-beta and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 and TGFB3 all function through the same receptor signaling systems.

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399
Custom Conjugations